Track-Hub of CADD scores for UCSC Genome Browser


This is information regarding the UCSC genome browser track hub for CADD versions v1.3 to v1.6 on hg19 and hg38. There is also limited support for NCBI genome data viewer and Ensembl genome browser. The track displayes the highest CADD score of any 3 possible SNVs for a genomic position. It is available for every determined (i.e. non-N) position on the major chromosomes of the reference genome.


To view the tracks in UCSC genome browser, you have to link to `hub.txt` available on our Repository. The simplest way to do this is to click here for hg19/GRCh37 and here for hg38/GRCh38.

For NCBI GDV: hg19/GRCh37 and hg38/GRCh38.

For Ensembl: hg19/GRCh37 and hg38/GRCh38.


Our latest manuscript describes the updates since the initial publication of CADD including these UCSC Genome Browser tracks. It was published by Nucleic Acids Research in 2018:

Rentzsch P, Witten D, Cooper GM, Shendure J, Kircher M.
CADD: predicting the deleteriousness of variants throughout the human genome.
Nucleic Acids Res. 2018 Oct 29. doi: 10.1093/nar/gky1016.
PubMed PMID: 30371827.
The original manuscript describing the CADD method was published by Nature Genetics in 2014:
Kircher M, Witten DM, Jain P, O'Roak BJ, Cooper GM, Shendure J.
A general framework for estimating the relative pathogenicity of human genetic variants.
Nat Genet. 2014 Feb 2. doi: 10.1038/ng.2892.
PubMed PMID: 24487276.

Data Access

The bigWig datasets displayed in these tracks are located on our webserver. The code for this track-hub is further hosted on GitHub


If you have technical problems using the CADD track-hub, please check the information provided in the readme. If this does not resolve your issues, please contact us at cadd-support [at]